I think this one really depends on which saint we're talking about. If it's St. Francis of Assisi, which would probably not be a bad guess as it's a Franciscan university, the eagle's probably going to win as the saint's not going to attack. If it's the patron saint of hunters (Hubertus, evidently), then the eagle's not going to stand much of a chance. I'm going to presume it's either Hubertus or Gummarus (lumberjacks) or Isidore of Seville (computer scientists) and give the win to Siena
#5 Utah Utes vs. #13 Cleveland State Vikings
Now that I've got all the Macchio out of my system in the first round, this seems like an easier decision. Utah's got purposefully weakened beer, wacky government (insofar as "backwards and borderline oppressive" can be considered wacky) and movies with Matthew Lillard and Jason Segel. Vikings have axes and Thor. Cleveland State wins.
#6 West Virginia Mountaineers vs. #3 Kansas Jayhawks
I don't know much about the mountaineering lifestyle, but I'm positive it involves shooting things, mythical or otherwise. In addition, the Kansas Jayhawk appears to be wearing giant yellow clown shoes.
I have no idea how he buckled them
That seals it. West Virginia advances.
#10 USC Trojans vs. #15 Robert Morris Colonials
USC, unfortunately and through no fault of their own, make me think of those annoying "Trojan Man" commercials, which are just this side of "five dollar footlong" in terms of sticking in my head. The Colonials stir up bad memories of a "Colonial Inn Diner" where a friend of mine tried to order eggs florentine before being told that the fact that there was a picture of it on the menu was not meant to imply that they served it. Overall, I'm going with Robert Morris, as we've got the matchup of two military factions and I feel like I should go with the one that won their war.